Professor Francis Barr

Francis Barr

Cell Growth and Division Group
Cancer Research Centre, University of Liverpool
Liverpool

Splitting up - understanding how cancer cells divide

Professor Francis Barr heads the Cell Growth and Division Group at the University of Liverpool. He is studying how cells divide to make new cells, focusing on the last step in the process of cell division, in which a single cell finally splits to create two ‘daughter’ cells. This is called cytokinesis.

In healthy cells this process works perfectly. But if cytokinesis goes wrong, then the cell may not be able to divide its genetic material correctly. The daughter cells may gain or lose vital genetic instructions, which may cause them to multiply out of control. This can lead to cancer.

Investigating molecules involved in cell division

Professor Barr and his team are studying some of the molecules involved in cytokinesis. In particular, they are investigating a protein called PRC1, which is needed in many of the critical stages of cell division. It forms a complex network with lots of other molecules in the cell, directing cytokinesis.

The researchers are using a number of sophisticated techniques to study PRC1 and other molecular players in cytokinesis. For example, they are using powerful microscopes to study where these molecules are located, and how they move around in living cells. These techniques will enable the researchers to see what happens in cells when some of these molecules are faulty.

A greater understanding of the molecules involved in cell division could point the team towards new targets for cancer treatments. And it may also lead to new ways of diagnosing cancer in the future.

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