Prof Gillian Tozer

Professor Gillian Tozer

Tumour Microcirculation group
University of Sheffield
Sheffield

Targeting the blood supply in tumours

Professor Gillian Tozer runs the Tumour Microcirculation Group at the University of Sheffield. She and her team are investigating the way that blood vessels grow within a tumour - a process known as angiogenesis.  They are seeking new ways of targeting this process in order to develop better treatments for cancer.

All parts of our bodies need a blood supply to provide oxygen and nutrients, including cancer cells. But the blood vessels that grow into tumours are different from those found in healthy tissue, and are relatively disorganised. Scientists believe that targeting tumour blood vessels could be a good way to treat cancer.

Professor Tozer and her team are looking at how blood vessels grow and mature within tumours. Using blood vessel cells grown in the lab and tissue from tumours, they are investigating the proteins that control these processes and how they affect patients' responses to treatment. They hope to discover targets for new cancer drugs and find ways of combining new treatments with conventional ones, such as chemotherapy and radiotherapy.

Scanning tumours

Working in collaboration with physicists and engineers, Professor Tozer is also developing ways to study tumours within the body, using imaging techniques such as MRI scanning. This enables her to monitor how well new anti-cancer drugs are working, and investigate their effects on a tumour's blood supply.

By studying the 'biological plumbing' in cancers, Professor Tozer hopes to find more effective ways to tackle this disease, which could lead to exciting new treatments in the future.

Browse related content

 

If you want to help support more research like this, please visit our Donate Now page.