Prof Margaret Frame
Cell Adhesion Signalling Laboratory
University of Edinburgh
Edinburgh
How do cancer cells spread - and how can we stop them?
Professor Margaret Frame and her team at University of Edinburgh are tackling one of the biggest challenges in cancer treatment - how to stop the disease spreading to other parts of the body. The researchers are investigating how cancer cells break away from a tumour and start moving, to find out how this process could be stopped.
Cells on the move
Cell movement is controlled by a number of different proteins - molecules inside cells that send messages telling cells to move or stay put.
Professor Frame is internationally recognised for her groundbreaking research on two 'messenger' proteins called Src and FAK, which play important roles in cell movement and are implicated in cancer spread. These proteins are overactive in cancer cells, sending too many messages that encourage the cells to move and spread.
Professor Frame's team are studying how Src and FAK work in healthy cells and in cancer. They are investigating how signals from these proteins make cells stick to each other or break apart, and how they become overactive in cancer.
Stopping cancer in its tracks
By understanding how these overactive proteins control the movement and spread of cancer cells, Professor Frame and her team hope to discover new ways to target cancer cells and develop new drugs to treat the disease.
Finding ways to block the messages coming from Src and FAK could halt the spread of cancer, providing powerful ways to treat the disease in the future.
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