This section contains information on the incidence of ovarian cancer by age and sex, geographic variation and trends over time. The ICD codes for ovarian cancer are ICD9 183 and ICD10 C56 and C57.
In 2005 there were 6,806 cases of ovarian cancer diagnosed in the UK. Table 1.11-4 shows the numbers and rates of new cases in the UK and its constituent countries. The lifetime risk of developing ovarian cancer is approximately 1 in 48 for women in England and Wales.
Ovarian cancer is the second most common gynaecological cancer in UK women after uterus (Table 1.2).
Ovarian cancer is predominantly a disease of older, post-menopausal women with almost 85% of cases being diagnosed in women over 50 years (5,745 out of 6,806 cases). There is a steep increase in incidence after the usual age of the menopause (Figure 1.1)1-4. The highest incidence rates are for women aged 65 and over.
Worldwide there are more than 204,000 new cases of ovarian cancer each year, accounting for around 4% of all cancers diagnosed in women5. Incidence rates vary considerably, with the highest rates in the USA and Northern Europe and the lowest rates in Africa and Asia5.
Around 43,000 cases occur each year in Europe and 22,000 in the USA. Within the EU the lowest rates are in the Southern European countries of Greece, Portugal and Cyprus, while the highest are in the Northern and Eastern European countries of Lithuania, Denmark, Czech Republic and Estonia (Figure 1.2 shows incidence and mortality for EU countries) 5.
Evidence from population migrant studies is conflicting. In a study of immigrants to Israel, those who migrated from a country with a higher incidence of ovarian cancer retained a similar level of risk as their country of origin, but within one generation the risks were no longer significantly different6. However, research in other migrant populations has not shown a similar pattern7-10.
The incidence of ovarian cancer in British women has increased over the last 30 years from around 15 per 100,000 women in 1975 to around 17 per 100,000 women in 2005, an increase of 18% whilst the mortality rate has decreased in a similar proportion from around 12 deaths per 100,000 women in 1975 to around 10 in 2006 (Figure 1.3)1,3,4.
Figure 1.4 shows the age-specific rates for ovarian cancer between 1975 and 2005 in Great Britain. Most of the increase in incidence in Britain has been in women over 65 years. Between 1975 and 2005 the incidence rate in women over 65 years rose from 43 to 67 per 100,000, an increase of 55%. Widespread use of the contraceptive pill is one possible explanation for the stability of rates in younger women.